Pfizer Material Scientist in Sandwich, United Kingdom
An essential component of Pfizer at Sandwich, our Pharmaceutical Sciences function supports Pfizer's early to late stage portfolio translating new chemical entities into commercial drug products. Pharmaceutical Sciences at Sandwich is a fully integrated CMC capability that encompasses state of the art active pharmaceutical ingredient synthesis and drug product design as well as a cGMP manufacturing and clinical trials supply chain. Within Pharmaceutical Sciences, the Drug Product Design (DPD) department utilises expertise in materials science, formulation design and process understanding to deliver innovative new medicines.
We are seeking a pharmaceutical materials scientist to work in a multi-disciplinary team environment engaged in the design, development and characterisation of active pharmaceutical ingredient (API) and/or pharmaceutical dosage forms.
You will predominantly be involved in a laboratory and 'hands-on' laboratory based role, working in DPD on assigned API and drug product projects. Your focus will be on designing impactful experiments and generating high quality data, focussed on the solid state, for the timely progression of new chemical entities and pharmaceutical dosage forms.
Under the mentorship of subject matter experts, your existing knowledge and experience will be enhanced through engagement in a programme of active learning and training tailored to accelerate your contribution to the diverse business of DPD - in particular, the design development, optimisation, scale-up and technology transfer of pharmaceutical dosage forms, complemented by active pharmaceutical ingredient (API) characterisation and solid form design, and understanding of biopharmaceutics.
Design and undertake high quality scientific experimentation to generate high quality data to further the development of API and/or dosage forms for novel drug candidates with a focus on API solid state and physical property characterisation, including the characterisation of the API within the drug product environment.
Apply physical property characterisation techniques to optimise the design and performance of API particle properties. Where appropriate, develop, validate and transfer into cGMP facilities physical property analytical methods to assure the physical properties of the API.
Apply spectroscopic and diffraction based analytical techniques to optimise the physical stability of the API within the drug product environment. Where appropriate, develop, validate and transfer into cGMP facilities appropriate analytical methods to assure the physical stability performance of the drug product.
Utilise the high quality analytical data to develop mathematical models capable of predicting the physical stability performance of the drug product.
Ensure own work, meets agreed project deliverables and stakeholder needs, maintaining quality and reporting findings either verbally or in written format, both within DPD and the wider Pharmaceutical Sciences project team.
Provide interpretation and contextualisation of data and model predictions to project team leaders and where appropriate make recommendations for further studies and/or quality control strategies.
Develop and maintain a contemporary in-depth understanding of the application of physical property/spectroscopy based analytics to the development of API and pharmaceutical dosage forms.
Participate on multidisciplinary project teams, and collaborate with colleagues to define and implement characterisation strategies according to project timelines.
Contribute to the authorship of regulatory submissions and support the patenting of Pfizer's intellectual property.
Oversee the work of external partners conducting laboratory studies, and provide tactical guidance and critical analysis of raw data.
Contribute to the department's operations by taking responsibility for one or more of a number of important roles that ensure the smooth running of the department. Examples of such roles include but are not limited to the following: instrument owner, lab steward, EHS and training roles.
Ensure accurate, timely entries are made in e-laboratory notebook system according to accepted good practice. In addition, compile and prepare high quality technical reports in relation to project work.
Ensure familiarity/compliance with appropriate documentation (SOPs, instruction manuals, risk assessments, etc.) so that all experimental/manufacturing-related activities are conducted in accordance with approved safety and quality procedures.
Degree, Advanced Masters degree or equivalent in pharmaceutical or allied scientific discipline (e.g. chemistry, pharmacy, pharmaceutical sciences, chemical engineering, etc.)
Significant experience in a material sciences laboratory environment
Ability to learn and apply established procedures quickly and reliably
Good verbal and written communicator
Accurate data recording skills
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.