Pfizer Translational Oncology Lead in La Jolla, California
As a member of the Translational Oncology group within the Global Products Development - Oncology organization, the successful candidate will function in a key scientific leadership position on clinical development teams to ensure that a current and experienced understanding of relevant human cancer biology, cancer therapeutics and clinical assay technologies is appropriately integrated into clinical development strategies.
The candidate will combine a deep understanding of cancer biology and human malignancies, as well as cancer immunology, with prior experience in clinical trial sample analyses to design, prioritize and successfully execute clinical translational studies that will inform key drug development decisions in the era of precision medicine.
Design, conduct and coordinate clinical and translational research activities involved in the evaluation and development of anti-cancer drugs within the Pfizer Oncology portfolio, focusing on pharmacodynamic proof-of-mechanism/pharmacology, patient selection/stratification and clinical proof-of-concept, and underlying disease biology of relevance to combination therapy and drug sensitivity or resistance
Identify, evaluate and prioritize candidate predictive biomarkers and develop clinical companion diagnostic tests that will appropriately transition from early to late phase clinical development
Work directly with academic collaborators and key opinion leaders as well as a variety of external contract research organizations/vendors to execute and expand clinical translational research efforts.
Work collaboratively within highly integrated, multi-functional program teams that include scientists within Discovery Research, Research Precision Medicine, Computational Biology, Clinical Pharmacology and Development Operations groups, as well as Clinicians, Statisticians, and Medicine Team Leads.
"Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact."
Training and Education:
Minimum: Advanced degree (PhD, MD, MD/PhD, Pharm. D.) with focus on cancer biology and biomarkers.
Candidates should possess an advanced and current understanding of cancer biology, cancer genetics and cancer immunology.
Prior Experience: (Dependent on Level)
Minimum: Five years or more of industry experience demonstrating excellence in designing, executing and interpreting studies of cancer biomarkers in clinical trials, including biomarker development, validation and clinical application; familiarity with clinical trial design, logistics and regulatory issues; familiarity with the development and regulatory approval of oncology companion diagnostics.
Demonstrated ability to think strategically and creatively while contributing to multiple projects and to work well in collaborative, multi-disciplinary team setting; effective verbal and written communication skills
Clinical Project Expertise : demonstrated potential or ability to design, initiate and conduct clinical studies focusing on integrating and executing biomarker analyses that support clinical development objectives
Scientific Excellence : demonstrated understanding of pre-clinical and clinical tumor biology, and the ability to apply that knowledge to drug development; demonstrated understanding of the complexities and recent developments in the relevant therapeutic/technical area, and the ability to apply such knowledge to drug development
Presentation and Analytical Skills : demonstrates ability to present clinical data, study plans and tactics clearly and accurately to relevant audiences to inform and direct decisions
Networking and Alliance Building : Able to work across many interfaces and line functions: clinical, regulatory; project management; development operations (biometrics, monitoring resource, study reporting); statistics; data management; programming; marketing / commercial
Developing Others : Will be responsible for helping to support and mentor as appropriate less experienced translational clinicians, and to foster continued learning within the therapeutic areas, including collection and application of lessons learned
I nfluencing : Must be able to lead multi-disciplinary groups; ability to manage and motivate investigators and contract research organizations
Innovation: Constantly challenge existing paradigms in clinical research and encourage breakthrough designs; work with clinical development operations on study design, data capture and retrieval, reporting
Courage with decisiveness to Act : Bias towards action to achieving goals
Team Building : Shares wins and success; fosters open dialogue; lets people finish and be responsible for their work; defines success in terms of the whole team; creates strong morale and spirit in his/her team; creates a feeling of belonging to the team; leads by example in fostering the values of excellence, courage, equity and joy
Conflict Management : Good at focused listening; can find common ground and get cooperation with minimum noise
Other Job Details:
Additional Location Information: La Jolla, CA and San Francisco, CA
Eligible for Relocation Package
Eligible for Employee Referral Bonus
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