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Pfizer Senior Scientist, Cytokine Biology Immuno in La Jolla, California

ROLE SUMMARY

Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics.

We are seeking to hire multiple Senior Scientists for the Cytokine Biology CID group.

ROLE RESPONSIBILITIES

  • Design and execute of mechanism of action (MOA), PD and other biomarker studies, as well as combination studies for CID's preclinical-stage cytokine therapeutics using in vivo murine models and ex vivo methods, such as cell sorting, multi-color flow cytometry, gene expression analysis techniques, and primary cell culture.

  • Discover and develop new therapeutic modalities for cancer immunotherapy focusing on cytokines as targets.

  • Perform studies to evaluate the contribution of cytokines to anti-cancer immune responses as well as cancer development and progression.

  • Collaborate with protein engineering, computational biology, T cell redirecting therapy group and clinical development group to pursue the most promising drug candidates through clinical trials.

  • Participate in collaboration on novel cytokine targets and therapeutics with internal and external collaborators.

  • Communication of research results to team and company.

  • Supervise research associates and/or scientists.

BASIC QUALIFICATIONS

  • B.S. degree with 10+ years' experience or M.S. degree with 7+ years of experience or Ph.D. with 1+ years of experience.

  • Experience in the fields of immunology, cell biology and/or genetics

  • Ability to independently design, plan and execute and interpret experiments

  • Ability to manage an independent research program with minimal supervision

  • Experience with various murine tumor and/or infectious disease models.

  • Expertise in standard immunologic techniques

  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic.

PREFERRED QUALIFICATIONS

  • Expertise in flow cytometry, qRT-PCR, MSD, Nano string and cytotoxic assays.

  • Experience in CRISPR technology and lentiviral transduction.

  • Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using, T-cells, monocyte/ macrophages, or dendritic cells).

  • Experience with human PBMC and mammalian cell culture.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Other Job Details:

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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