Pfizer Senior Scientist, Biochemistry/Bioconjugation in La Jolla, California
BioMedicine Design (BMD) is seeking a highly motivated and innovative scientist to join a protein engineering group supporting the Biotherapeutics portfolio of Pfizer, Inc. in La Jolla, CA. Responsibilities will be driving therapeutic innovation through technology development and contributing to the pipeline, including conducting and optimization of reaction, purification, and characterization of bioconjugates of antibodies or fusion proteins with small molecules or imaging agents. In-depth understanding of biochemistry and expertise in complex synthetic and bioconjugation chemistry and separation will be essential to this position.
Integral member of a highly-collaborative team executing on time-sensitive protein engineering projects all the way from antibody/antigen design & generation through protein purification and characterization.
Independently design, conduct, trouble-shoot protein biochemical and conjugation experiments
Evaluate key quality attributes of fusion proteins, antibodies, and bioconjugates
Serve as the subject matter expert for biological assays, biochemical assays and bioconjugation, improve existing processes
Desire to understand underlying biology and mechanism of targets and biologics.
Present results regularly at team meetings and drive data-driven decisions
Perform diligent and timely note-keeping and work process tracking
PhD in chemistry/biochemistry/chemical biology or a related discipline
Extensive hand-on experience with protein biochemistry and bioconjugation with state-of-the-art knowledge of diverse conjugation methods
Technically proficient in protein engineering tools, including construct design, molecular biology (restriction cloning, Gibson assembly), protein expression in E.coli and mammalian/insect cell systems, protein purification (affinity chromatography, SEC, ion exchange, gravity or chromatography mode) and characterization (SDS-PAGE, RP-HPLC, analytical SEC, and mass spectrometry, in vitro activity).
Knowledge of basic pharmacology principles and drug delivery
Experience with data analysis and presentation software
Excellent written and oral communication skills
The individual should be scientifically creative and driven by a willingness to embrace innovation within drug discovery and an eagerness to challenge and meet aggressive timelines
An innovator with track record in molecular design of biologics, of creative and proactive approach to problem solving, and strong analytical skills.
Strong motivation, passion and commitment to science and engineering of novel entities
Ability and desire to work in an interdisciplinary scientific team and the desire to learn new techniques
The ability to work closely with other group members within teams is essential
R&D experience in an industry setting with good understanding of biologic drug development or 2+ years of postdoctoral experience
Prior experience in antibody-drug conjugate research
Experience with antibody/protein expression and purification
Training in enzymology
Understanding of biodistribution, metabolism, and modeling tools
Other Job Details:
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Research and Development