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Pfizer Senior Principle Scientist, Molecular Pharmaceutics in La Jolla, California


Scientific and strategic leadership role in Molecular Pharmaceutics Group to support early stage drug product design and biopharmaceutics profiling of new small molecule oncology drugs. Provide guidance and recommendations to drug discovery project teams on biopharmaceutics implications and formulation considerations for the design and selection of new drug candidates. Interface with multi-disciplinary project teams to provide formulation knowledge and expertise and to communicate the interpretation and implication of experimental and computational results towards bringing new molecules into development. Partner with Pharmaceutical Science project teams to enable the realization of successful clinical outcomes in early clinical trials and acceleration of pivotal clinical studies. Develop and use advanced modeling & simulation tools for predictive performance of oral absorption and utilization of enabling drug delivery technologies to achieve desirable delivery profiles. Use knowledge of solubility, dissolution, permeability and intestinal transport mechanisms to optimize early stage pre-clinical and clinical formulations. Develop and advance concepts of translational biopharmaceutics with a focus to improve predictive capabilities by linking in vitro drug product performance attributes to in vivo performance attributes. Maintain an awareness of and contribute to current scientific literature; actively apply new concepts as appropriate. Conduct novel scientific research and present significant findings via internal and external presentations or publications.


  • Drug Product Design project representative on Oncology Discovery Project Teams providing scientific leadership and strategic direction for the drug discovery of new Oncology small molecule drug candidates.

  • Integrates biopharmaceutics and formulation discipline knowledge into the broader project team to help guide project decisions.

  • Lead formulation project teams up to POC in the clinic.

  • Considered a subject matter expert in formulations and biopharmaceutics.

  • Cultivates sustainable and effective relationships with internal partners and stakeholders, i.e., partner lines in PSSM, Clin Pharm, DSRD, ORU, DPM.

  • Growth opportunity to lead a group of 3-4 junior scientists in the group


  • PhD in Pharmaceutics, Physical Chemistry , Pharmacokinetics or related discipline with 5-10 years relevant experience in oral absorption and small molecule drug product design or BS/MS in Pharmaceutics, Physical Chemistry, Pharmacokinetics or related discipline with a minimum of 12-15 years relevant pharmaceutics industry experience in small molecule drug product design.

  • Recognized expert and industry experience in Formulations and/or Biopharmaceutics, Pharmacokinetics and a strong record of scientific achievement & project influence.

  • Experience in using and interpreting biopharmaceutics modeling, physicochemical (solubility & dissolution) and biological (passive, transporter mediated, efflux) transport phenomena, interpretation and use of in-vitro permeability measurements, or in-vivo/in-vitro drug metabolism studies, and interpretation of pre-clinical pharmacokinetic data for the design and selection of new molecules.

  • Extensive practical experience of project liaison and achieving results in a matrix environment.

  • Proven track record of influence on projects and project teams.

  • Experience in drug discovery / development up to proof of concept studies.


  • Excellent organizational skills, the ability to work independently, and excellent oral and written communication skills are required.

  • Proven track record of mentoring and coaching junior scientists

  • A strong interest and motivation to learn and implement new technologies and concepts is expected.

  • General understanding of drug discovery, chemistry and pharmacology- Oncology preferred.

  • Collaborative skills and effective partnering skills in a complex, multi-discipline organizational model.

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Additional Info

Other Job Details:

  • Eligible for Relocation Package Yes

  • Eligible for Employee Referral Bonus Yes

N (Other) (United States of America)

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.