Pfizer Scientist in La Jolla, California
Pfizer Vaccine Research and Development seeks to discover novel vaccines (prophylactic and therapeutic) for the prevention and treatment of significant human diseases (e.g. infectious diseases, oncology) using a variety of vaccine technology platforms combined with immunomodulatory agents.
We are seeking a Virus Production/Purification Scientist to join the Early Bioprocess Development group in Vaccine Research, La Jolla, California, to develop and support virus production/purification processes at the research scale.
The successful candidate will have good knowledge and experience in virus production and purification and be able to independently and proactively apply this knowledge to the design and execution of experimental work, enabling progression of vaccine discovery projects from preclinical to early development. The role will encompass both preclinical reagent supplies along with early process development for clinical vaccine candidates.
EXPERIMENTAL/LABORATORY & RELATED WORK under daily to weekly supervision (80-90%):
Work with supervisor to define aim and a plan to achieve that aim, will then independently execute work following the plan
Experimental design in consultation with supervisor, literature review, and increasing emphasis on independent design based on experience.
Will carry out on-going analysis of data generated and will identify problems. Will implement necessary changes following discussion with peers/ supervisor.
Will analyze and interpret experimental data, results and methodology used with guidance.
Will gain skills and experience to be fully conversant with the operation and validation of all items of equipment or IT needed for experimentation, data analysis, storage and data entry.
Be able to review literature and suggest/apply to technical solutions to bioprocess problems of moderate complexity
Will write-up laboratory notebooks regularly in compliance with Pfizer IP policy and GSP
Preparation of presentation materials.
COMMUNICATION & Scope of Team Influence
Will have effective communication skills, both verbal and written; listens and understands well.
Will regularly communicate with supervisor and team scientists
Will regularly contribute and influence at the discipline and project team level as a team participant.
Safe working and regulatory compliance
Work safely themselves and be aware of EHS practices of other colleagues in all aspects of role, including handling of BSL2 infectious viruses.
Completion of risk assessments, compliance training as required
Acts independently to maintain a safe and EHS compliant desk and workspace
Bachelor of science degree in biological sciences or Biochemical/chemical engineering with 6+ years' relevant laboratory experience, or Master of science degree in biological sciences or Biochemical/chemical engineering with 5+ years' relevant laboratory experience.
Experience in one or more of the following areas is essential:
Mammalian cell culture - adherent and suspension
Virus production at bioreactor scale
Virus and/ or protein purification using chromatographic techniques - with experience using Unicorn based FPLC systems.
Tangential flow filtration
Ultracentrifugation based purification
Experience in safe handling of BSL2 infectious viruses - e.g. Adenovirus & Vaccinia
The successful candidate will be required to work with BSL2 infectious viruses- Including Vaccinia
The candidate will be required to work with moderate supervision and, as a member of a team, be accountable for the critical appraisal of their results and present them for review, at specific project milestones. The role is laboratory based, and a major emphasis is placed upon laboratory training to increase the scope of practical abilities, as well as the theory behind such practical work.
- Virus and/ or protein characterization techniques
Standard laboratory conditions - sitting, standing, primarily lab based
Ability to lift up to 30 lbs
Working with BSL2 infectious viruses
Ability to perform mathematical calculations and complex data analysis
Will be required to work with BSL2 infectious viruses (e.g. Vaccinia virus, adenovirus, and influenza) and must receive and maintain required vaccinations or provide satisfactory proof of same.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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Other Job Details:
- Eligible for Employee Referral Bonus
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.