Pfizer Scientist (non in La Jolla, California

Cancer progression is a manifestation of genetically induced changes in the dynamic interaction of many cellular components. To guide oncology discovery campaigns at Pfizer, the newly formed Cancer Systems Therapeutics (CST) group located in La Jolla will develop cutting-edge systems biology tools, such as phenotypic screens, genome-wide genetic screens, functional genomics, proteomics and chemical biology, to quantify global cellular perturbations induced by oncogenic changes and by small molecules aimed at counteracting such changes. Team members will apply systems biology-based disciplines to identify novel oncology targets to deepen our understanding of anti-cancer programs under development.

We are seeking an experienced cell and molecular biologist to contribute to the success of the CST group within the Tumor Cell Biology (TCB) Department. The candidate should have expertise in cellular engineering technologies, target identification and validation in a drug discovery context. This is an exciting opportunity to apply cutting-edge methods and contribute to the target portfolios of the Oncology Research Unit of one of the world's leading developers of novel therapeutics.


  • Carry out experiments to test the functional consequences of genetic variants in cell-based model systems using methods that include CRISPR-based gene editing technologies and RNA interference

  • Perform CRISPR- and shRNA-based screens to identify new targets

  • Contribute to developing tool assets for advancing CST group projects including generation and maintenance of cell lines, chemical probe validation, and molecular library construction

  • Serve as a technical resource within CST group for engineering and generating stable cell lines, genome-wide gene editing screens, chemical biology or other technologies

  • Work closely with other CST lab personnel, and maintain close and productive interactions with the TCB lab personnel

  • Assist with the evaluation of new approaches and technologies within the CST group

  • Stay current with relevant technologies including those relating to molecular and cell biology, and biochemistry

  • Contribute to building a culture that embraces continuous learning and improvement

  • Help to establish the CST group as an integral component of world-wide research development


  • Bachelor's degree in molecular biology or related field with at least 6+ years laboratory experience in an industrial or academic setting

  • Experience with an array of molecular biology methods, including cloning, vector construction, PCR, DNA and RNA isolation, and library construction

  • Expertise with a variety of cell biology techniques, including cell culture, engineering and generation of stable cell lines, lentiviral production, PCR-based expression analysis, protein expression analysis, and cell-based assays

  • Experience in functional genomics screens, CRISPR-based gene editing, RNA interference technologies

  • Track record of successful contribution to research projects, preferably utilizing gene editing or screening methodologies

  • Ability to effectively interact and collaborate with other scientists, both within the group and in other groups; excellent communication and interpersonal skills


  • Next-generation sequencing, single cell technology, or 3D organoid model experience is a plus

Other Job Details:

  • Eligible for Employee Referral Bonus

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