Pfizer Scientist, Immunosuppression Immuno in La Jolla, California
Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. We are seeking to hire multiple Scientists for the CID Immunosuppression group.
Evaluation of novel mechanisms of tumor resistance to innate and adaptive immunity
Execution of cell-based functional and biochemical assays to select candidate molecules for clinical development.
Planning and execution of in vivo murine studies and ex vivo functional assessments, such as, multi-color flow cytometry, i mmunohistochemistry/immunofluorescence, and primary cell culture.
Communication of experimental results to team.
B.S. degree with 6+ years' experience or MS (preferred) with 5+ years of experience
Experience in the fields of immunology, cell biology and/or genetics.
Ability to plan and execute and in vitro experiments with minimal supervision
Expertise in standard immunologic techniques
Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells).
Experience with human PBMC and mammalian cell culture.
Experience with qRT-PCR, ELISA, MSD, ELISPOT, Nano string and cytotoxic assays.
Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic.
Immune phenotyping tumor associated immune cells from primary human tumor samples by flow cytometry.
Experience in CRISPR technology and lentiviral transduction.
Experience working with small molecules inhibitors for tumor immunotherapy.
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Other Job Details:
Eligible for Relocation Package
Eligible for Employee Referral Bonus
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