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Pfizer Principal Scientist Protein Expression and Molecular Biology in La Jolla, California

BioMedicine Design (BMD) is seeking a highly motivated scientist to lead a protein expression and molecular biology group supporting the Biotherapeutics portfolio of Pfizer, Inc. in La Jolla, CA. The candidate will be responsible for leading a group of scientists focused on protein expression and DNA construct generation to support the generation of milligram to gram scale quantities of recombinant proteins. Constructs will include biotherapeutic leads, protein reagents, immunogens, and phage/yeast display reagents. This position requires strong expertise in cutting-edge mammalian tissue culture techniques using various cell lines and cell culture technologies. The ideal candidate will be highly proficient in the design of optimal processes that are consistent with team material needs for quantity and purity.

Job Description:

  • Responsible for the protein expression and molecular-related deliverables of the La Jolla BioMedicines Design protein production group

  • Manage and lead protein expression/molecular biology scientists. Mentor and support career development

  • Supervise/perform protein expression in mammalian transient and stable expression cell lines, from various shake flask scales to bioreactor systems

  • Supervise, perform and/or coordinate the generation of DNA constructs tailored for the expression of recombinant proteins

  • Assume a leadership role for the BioMedicine Design portfolio by acting as Engineering Lead for at least one biotherapeutics discovery-stage project

  • Design, assess and troubleshoot cell culture and expression protocols

  • Periodically assess site practices and promote the evaluation of new methods and technologies for protein expression and construct generation to optimize delivery to project teams

  • Supervise the delivery of cell culture supernatants and data analysis packages to project teams in a timely manner

  • Present results regularly at team meetings

  • Perform diligent and timely notekeeping and work process tracking

Required Qualifications:

  • PhD in molecular biology/biochemistry/immunology/cell biology or a related discipline, 2+ years of postdoctoral experience, with 3+ years R&D experience in an industry setting OR BS/MS with 15+ years of industry experience

  • Detailed understanding of the scientific and technological principles behind state-of-the-art protein expression systems

  • Good understanding of the broader biotherapeutics drug discovery process

  • Extensive experience in protein expression using transient and/or stable mammalian cell culture systems

  • Strong expertise in design, execution, and troubleshooting of expression processes

  • Extensive expertise in molecular biology techniques, including primer design, PCR, mutagenesis and subcloning techniques, and E. coli cell culture

  • Experience with antibody and biotherapeutic expression and a working knowledge of antibody molecules

  • Experience with data analysis and presentation software

  • Excellent written and oral communication skills

Preferred Qualifications:

  • 2+ years of experience in a supervisory role

  • Experience with Insect Cell expression systems would be highly desirable

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Other Job Details:

  • Eligible for Relocation PackageEligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.