Pfizer Principal Scientist, Phage/Yeast Display, Antibody Discovery in La Jolla, California
Pfizer's Biotherapeutic Discovery group in La Jolla is seeking an outstanding and highly motivated Principal Scientist to aid in our biologics discovery, engineering and technology development projects. They will be responsible for working closely with individuals in both protein engineering and biology to develop the next generation of biologics. They will have access to state-of-the-art antibody generation technologies and will be expected to continue our tradition of developing world class methods and technologies that enhance our therapeutic antibody discovery efforts.
Responsible for isolating and optimizing antibodies using Pfizer's proprietary synthetic antibody libraries.
Work within a multidisciplinary and cross-functional team to advance biologics through different stages of the development
Generate highly diverse libraries and set up selections to obtain the desired function
Comfortable working with automation methods using liquid handling equipment
Independently design experiments, analyze data and troubleshoot methods
Desire to understand underlying biology and mechanism of targets and biologics.
Present experimental design and results at internal meetings
PhD in Biological Science (Molecular Biology, Structural Biology, Protein Biochemistry, Cell Biology) or a related field (Chemical Engineering, Biomedical Engineering and Biological Engineering) with postdoctoral experience and 3+ years of experience in an industry setting
Experience with using molecular biology to build libraries or perform high throughput cloning
Experience with using phage or yeast display
Experience engineering proteins with desired properties
Technical expertise should include molecular biology, protein expression/purification and characterization.
Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals and/or intellectual property generation.
Track record of demonstrating analytical skills, creativity and unique problem solving
Outstanding pro-active attitude, interpersonal, collaborative and oral communication skills
Strong motivation, passion and commitment to science and engineering novel entities
Ability and desire to work in an interdisciplinary scientific team and the desire to learn new techniques
Strong time management skills and ability to manage multiple projects in parallel
Ability to analyze and interpret work published in the field and apply it appropriately
The individual should be scientifically creative and driven by a willingness to embrace innovation within drug discovery and an eagerness to challenge and meet aggressive timelines
Previous experience with protein expression and purification methods
Previous experience with antibody engineering
Previous experience with high throughput screening methods
Experience with mammalian display
Understanding structure-function is a plus.
Physical or Mental Requirements
- Ability to perform mathematical calculations and ability to perform complex data analysis tasks.
Other Job Details:
Eligible for Employee Referral Bonus: Yes
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Research and Development