Pfizer In Vivo Principal Scientist in La Jolla, California

ROLE SUMMARY

We seek an accomplished Principal Scientist level oncology scientist to join the in vivo pharmacology group within Oncology Research & Development (ORD) in La Jolla, California. The successful candidate will join a dynamic team of scientists in the Oncology In Vivo Pharmacology Group, playing a leading role in guiding project teams in the appropriate planning and use of models of cancer to evaluate new drug candidates.

The Principal Scientist/In Vivo Lead will participate in pre-clinical drug discovery and development projects with a focus on immuno-oncology while also contributing to projects related to signal transduction, targeted therapeutics, and epigenetics. The successful candidate will be responsible for working with project teams to design and plan an in vivo strategy and both short and long-term planning of in vivo study plans to ensure efficient project decision-making. They will also be a key contributor to the In Vivo Committee, responsible for presenting study plans and obtaining peer input for protocol finalization and approval to meet research project objectives. The individual will directly supervise approximately 5 laboratory staff that make up an in vivo team responsible for study performance and data analysis. The Principal Scientist will provide technical and scientific expertise in in vivo pharmacology across ORD to enable target identification, validation, prioritization and efficient drug discovery. Ideal applicants will possess excellent communication, leadership and organizational skills, critical problem-solving abilities, and a commitment to excellence.

ROLE RESPONSIBILITIES

  • Establish scientific in vivo strategy and study plans for drug discovery projects.

  • Serve as the in vivo pharmacology lead for several drug discovery projects.

  • Works within multi-functional teams to support drug discovery and combination therapy.

  • Works across In vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology.

  • Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.

  • Develop and characterize new in vivo mouse models, including syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted Interpretation, presentation and documentation of experiments as well as preparation of reports.

  • The Principal Scientist will generate and be accountable for the necessary Animal Use Protocols that ensures team members comply with all regulatory requirements and internal policies.

  • Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team.

  • Responsible for contribution to relevant in vivo sections of study reports and regulatory documents i.e. IND filings. Written and verbal presentation of results within a multidisciplinary team environment. Ensure that projects have all critical in vivo data to enable project stage dependent decisions. Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.

BASIC QUALIFICATIONS

  • Ph.D. in Cancer Biology, Immunology, Biochemistry, Genetics or equivalent experience in a related discipline with > 5 years industry experience with technical and scientific experience in drug discovery and preclinical development.

  • Experience in collaborative research in Oncology drug discovery programs.

  • Expertise in animal models of human cancers as well as strong publication record or evidence of equivalent achievements in industry are desired.

  • Expertise with GEMM and humanized models highly desirable. Hands on in vivo skills (IV, PO dosing), blood/tissue collection.

  • Excellent written and oral communication and presentation skills in English. Proficiency in all common office and scientific software.

PREFERRED QUALIFICATIONS

  • Supervisory experience is a significant plus

OTHER JOB DETAILS

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

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