Pfizer Scientist Molecular Biology/Genetics in Kalamazoo, Michigan
The position of Scientist - Molecular Biology/Genetics will work as part of an interdisciplinary team to improve Pfizer's production processes through biotransformation, biocatalysis and microbial culture improvement projects.
Principal duties include enzyme engineering/evolution, high through-put screening, strain construction and improvement, pathway and metabolic engineering, and development of new molecular biology tools to accomplish these tasks.
The Bioprocess Development Group (BDG) is a group of 25 highly engaged scientists that apply state of the art genetic, microbiological, engineering and analytical technology to support the lowest cost production of small-molecule active pharmaceutical ingredients (API) via enzymatic and fermentation processes.
Improve production strains by molecular biological methods and by traditional mutagenesis and screening.
Identify and evolve enzymes for increased activity, specificity and selectivity.
Determine and understand metabolic or reaction pathways and genetically engineer those pathways for improved culture performance and/or to produce new APIs.
BS in Molecular Biology, Biochemistry, Microbial Genetics or related fields with 2-5 years of experience
MS in Molecular Biology, Biochemistry, Microbial Genetics or related fields with 0-3 years of experience
- Experience working with genetic modification of E. coli, actinomycetes, yeasts, and/or other important industrial micro-organisms.Industrial or lab experience (non-coursework) and experience with nonconventional yeastspreferred.
Strong knowledge of molecular genetics techniques and computer software, and operation of molecular biology related instrumentation especially with industrially relevant microorganisms.
Skill and working knowledge in bioinformatics, including competence in using common desktop bioinformatic apps such as DNA Star, Vector NTI, CLC Bio Main/Genomics Workbench and Geneious.
Ability to analyze, interpret, and communicateexperimental data.
Strong initiative and good problem solving skills. Takes personal responsibility for own work, pushing self and others to exceed goals and deliver results.
Must have demonstrated communication skills, both written and oral.
Must be able to establish positive colleague relationships which foster collaboration and cooperation.BDG is a team-based organization.Good peer relationships are the only way to get projects done and to succeed.
Change agile - can effectively cope with change.
Lab position: Frequent standing and walking, frequent detailed manual manipulations, and computer-based work.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
First shift position - some overtime and/or weekend work may be required.
OTHER JOB DETAILS
- Last Date to Apply: May 21, 2020
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Research and Development