Pfizer Scientist, In Vivo Pharmacology in Groton, Connecticut
The Internal Medicine Research Unit (IMRU) is committed to finding cures for metabolic disorders. Within the IMRU, the Metabolism group focuses on identifying novel therapies to improve metabolic disorders associated with Type 2 Diabetes and fatty liver disease. We are seeking a highly motivated, scientifically and technically strong in vivo research scientist with a common goal of developing drugs to combat these metabolic disorders.
The successful candidate will organize and conduct non-human primate efficacy studies to support the IMRU portfolio. He/She will be responsible for the operations of maintaining a large non-human primate (NHP) colony to support in-vivo efficacy studies. The candidate will be responsible for maintaining animal experimental records, and for adherence to all IACUC, local and federal guidelines. Additionally, the candidate will be able to communicate and work well both within a team and across support lines.In addition, the successful candidate will assist with rodent studies, coordinate in vivo pharmacology studies, conduct mechanistic investigations using tissues, and communicate with research unit scientists. The candidate will contribute in a team environment to research projects from early target validation to late stage drug development.
Successful candidates are expected to:
Have knowledge, experience and skill sets in NHP handling, dosing (PO, IV, SC), blood collection, rodent (mouse and rat) handling, dosing (PO, SC, IV), blood and tissue collection
Perform in vivo experiments to address key mechanistic and pharmacological scientific questions such as efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
Data Analysis, interpretation, documentation of experiments and presentation of results within a multidisciplinary team environment.
Demonstrate understanding of different animal models of metabolic disease (NHP and rodent) and the utilization of these models for in vivo studies
Characterize new in vivo models (NHP and rodent) to study biologic mechanisms and support exploration of novel therapies.
Work efficiently and flexibly in a team environment
Apply scientific and technical expertise to drug discovery programs to impact the future of new drug candidate development.Ability to follow novel scientific or technological developments, and to implement them in the laboratory. Maintain a 'cutting edge' awareness of preclinical scientific, health and technical developments. Apply scientific and technical expertise to drug discovery programs.
Communicate and present study results in internal meetings.
BS/BA in biology or related discipline with 3+ years of NHP/in vivo experience in pharmaceutical or biotech industry.
Prior experience in NHP and rodent models relevant to human metabolic diseases.
Possess strong written/verbal communication skills and ability to effectively collaborate with scientists working in other disciplines.
Knowledge and expertise in the field of metabolic disease
Prior knowledge of statistics and commonly used processing software (Graph Pad Prism, SAS)
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Other Job Details:
- Last Date to Apply for Job: October 24, 2018 Eligible for Employee Referral Bonus
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