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Pfizer Bioanalytical Associate Scientist (non in Groton, Connecticut

ROLE SUMMARY

This colleague provides quantitative analysis of drugs and metabolites from biological matrices to support Pfizer's Small-Molecule Global Discovery portfolio. This is accomplished through sample preparation using automated and manual techniques and analysis using liquid-chromatography/mass spectrometry. Colleagues are responsible for the development of "fit-for-purpose" assays and the associated assay troubleshooting and data analysis.

ROLE RESPONSIBILITIES

The primary role of the bioanalytical scientist is to provide quantitative analysis of drugs and metabolites from biological matrices in support of drug discovery programs. Fluid and tissue samples from non-regulated in vivo studies are analyzed to assess the pharmacokinetic/pharmacodynamic properties of new chemical entities. This position requires knowledge and experience in the development of quantitative analytical methodologies using primarily triple-quadrupole mass spectrometry. Knowledge of sample preparation, liquid chromatography, and analytical instrumentation are needed as these colleagues are expected to identify assay issues, and perform the associated trouble-shooting. The bioanalytical scientist is expected to utilize assay automation and IT processes to enable efficient bioanalytical support and to recognize opportunities for bioanalytical process improvement. This position supports a dynamic and complex portfolio so the scientist will experience changing priorities and must be able to balance analytical rigor and resource burn with the study's goals. The scientist must demonstrate good written, oral and interpersonal communication as they will interact with cross-functional partners and bioanalytical teams and are expected to promote and share new bioanalytical practices and techniques within the group.

BASIC QUALIFICATIONS

  • B.A. /B.S. degree in chemistry, biochemistry or related field is required with undergraduate research emphasis on the utilization of liquid chromatography, mass spectrometry, or in vivo sample preparation for quantitative analysis or B.A. /B.S. degree with 1-3 years of experience in quantitative analysis from biomatrices.

  • Desired: M.S. degree in analytical chemistry with a research emphasis on the utilization of liquid chromatography, mass spectrometry, or in vivo sample preparation for quantitative analysis or M.S. degree with 1-3 years of experience in quantitative analysis from biomatrices.

  • This position is not open at the Ph.D. level.

  • Good organizational, oral and written communication skills

  • Demonstrated ability to work in a matrix team environment

PREFERRED QUALIFICATIONS

  • Experience in the preparation of biological samples by protein precipitation, solid-phase extraction and liquid-liquid extraction

  • Experience in the development of liquid chromatographic separations

  • Experience in the operation of triple-quadrupole mass spectrometers.

  • Experience in the operations of automation and robotics.

  • Knowledge of the underlying principles of chromatography and mass spectrometry

  • Knowledge and experience with research informatics systems and tools such as WATSON LIMS

  • Demonstration of process continuous improvement.

  • Demonstrated ability to investigate and develop new bioanalytical approaches and strategies either independently or through collaboration.

PHYSICAL/MENTAL REQUIREMENTS

Lifting mobile phase bottles, 1-2 gallon waste LC-MS containers, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis. Ability to use pipettes, and centrifuges, etc. Ability to wear masks when working with highly potent biotherapeutics (OEB5) and the ability to work in safety hoods for extended hours.

OTHER JOB DETAILS:

  • Last Date to Apply for Job: 5/17/2019

  • Eligible for Employee Referral Bonus

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

N (Other) (United States of America)

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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