Pfizer VP, Gene Therapy in Cambridge, Massachusetts
The VP of Gene Therapy will lead and manage a group of 30 scientists within the Rare Disease Research Unit (RDRU) focused on expanding our leadership in developing transformative solutions for patients with high unmet need. He/she will be a driver of innovation and scientific excellence, contributing to ensure that our discovery and translational research are responsive to rapidly breaking science and evolving global healthcare demands related to gene therapy. The VP of Gene Therapy will be an experienced leader who will oversee Pfizer Gene Therapy Unit in Cambridge, MA and Raleigh, NC. He/she will also partner with colleagues in other scientific disciplines contributing towards the development of gene therapeutics and advancing them towards clinical testing. Demonstrated expertise in AAV vectorology, translational research in rare diseases and delivery of clinical candidates for development is desirable.
• As a member of the RDRU LT, set priorities that are aligned with the strategic direction of the Rare Disease Category's Leadership to grow the rare disease portfolio at Pfizer.
• Lead and manage a group of 30 scientists responsible for conceiving and developing new gene therapeutic concepts, AAV vector design and development, and translational research to advance the concepts toward clinical testing
• Partner closely with members of the RDRU to identify, implement and progress new gene therapy projects.
• Partner with other disciplines of integrated drug discovery and development, especially pharmacokinetics and drug disposition, Drug Safety, Regulatory, and Early Clinical Development, to develop translational preclinical packages for gene therapy clinical candidates. Collaborate closely with Pharmaceutical Sciences to identify and develop manufacturing processes for clinical grade viral vectors at scale.
• Ensure scientific strategy for each drug discovery project is rigorous, aligned and effective.
• Influence the global external environment through thought leadership, external visibility and active engagement with key opinion leaders.
- Build upon Pfizer's leadership in rare diseases through publication of peer-reviewed research articles, patent filings and speaking engagements at national and international conferences.
• Foster a collaborative and productive environment between Pfizer RDRU and academic biomedical researchers.
• Ensure all activities executed comply with legal and regulatory requirements and with Pfizer corporate policies.
• Build an "intelligence" capability and external network of biomedical research collaborations and advisors to find the most attractive gene therapy indications.
• Ensure projects are adequately resourced and prioritized to deliver on objectives.
• Eliminate barriers and silos that inhibit collaboration across departments and line functions and foster a culture of open collaboration, communication and transparency.
• Clearly communicate and articulate the vision and strategy to stakeholders and regularly report on portfolio progress.
• Inspire, model, and reinforce colleague expectations of urgently creating value at an appropriate return on investment, of applying innovative, rigorous science to discovering new medicines, of individual & collective accountability for value creation, and of continuously improving organizational effectiveness.
• Serve as a role model to Pfizer colleagues by maintaining the highest standards of scientific rigor and ethical principles. Nurture a culture that promotes challenging and respectful interactions among Pfizer colleagues and their external consultants and collaborators.
• Build a cohort of colleagues with the quality of scientific leadership and external recognition to generate competitive advantage in attracting the best talent and collaborators.
• Engender a high level of engagement across both direct and indirect lines.
• Attract and grow highly effective scientists and drug discoverers and nurture a culture that translates breaking biological science into new medicines that are differentiated from the competition.
- Effectively, rigorously and accurately review and develop talent. Proactively address development needs and make difficult decisions when appropriate.
Training & Education Required:
• M.D., Ph.D., or M.D./Ph.D.
• Deep working knowledge of gene therapy and rare disease biology
• Experienced leadership and management skills
Prior Experience Preferred:
• 15 or more years experience in translational or clinical research
• Demonstrated deep biological expertise and innovative record of research in a relevant therapeutic area; recognized leadership in the scientific or clinical community.
• Established record of delivering high quality drug candidates
• Established national and international scientific reputation
• Demonstrated track record of high impact publications
• Record of team leadership including change management experience
• Entrepreneurial mindset
• Scientific leader in his or her field as demonstrated by external recognition and reputation (e.g. publications, editorial appointments and podium presentations at top level scientific meetings)
• A compelling and inspiring leader with a sharp scientific mind, who combines broad knowledge and understanding of biological systems; a world-class leader in his/her field of biomedical research.
• Decision making and problem solving profile that enables marrying emerging science with unmet medical need to identify potential breakthrough medicines. Uses this experience to build a sustainable pipeline of drug candidates. Adept at separating important from unimportant information.
• Combines knowledge from multiple sources to generate novel and high impact ideas. Gets to the core of the problems, asks insightful and probing questions and gets to the next steps effectively.
• Strategically and rigorously assess projects in light of overall pipeline strategy and quickly and decisively advances or terminates projects.
• Disaggregates complex problems to facilitate problem solving.
• Business "mindset"; teases out and understands risks inherent in drug discovery and makes decisions appropriate to opportunity and investment required.
• Thinks laterally, connecting seemingly unrelated data, information, perspectives etc, at people, scientific and business levels.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
Eligible for Relocation Package
Eligible for Employee Referral Bonus
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.