Pfizer Senior Scientist, Antibody Discovery, Biomedicine Design in Cambridge, Massachusetts
We are seeking a highly motivated antibody display technology scientist to join our antibody discovery group in the BioMedicine Design Department at Pfizer, Inc. in Cambridge, MA. The candidate will be responsible for developing antibodies for validation of new therapeutic targets. The primary responsibilities of the candidate will be hit identification and lead optimization from antibody phage display libraries, working closely with multiple research teams. The role requires a strong background in molecular biology, tissue culture, bacterial culture, assay development, and high- throughput screening. Experience with automated liquid handling systems is strongly desired. The successful candidate should demonstrate a strong passion for life science and an ability to thrive in a fast-paced collaborative environment.
Design and execute antibody discovery campaigns using phage display technology against multiple targets in parallel.
Develop, optimize, and execute assays for high throughput antibody screening using robotic liquid handling equipment.
Manage relationships with internal research unit partners.
Characterize IgGs by analytical techniques such as ELISA, flow cytometry, and Octet.
Conduct high throughput molecular biology operations such as reformatting scFv to IgG. Design and build phage optimization libraries.
Independently analyze data and troubleshoot methods. Present experimental design and assay results at internal meetings.
Accurately document experimental design, data analysis and conclusions.
B.S or M.S in molecular biology/immunology/cell biology or a related discipline with a minimum of 5 years of research experience OR a PhD in molecular biology/ immunology/cell biology or a related discipline
Minimum of 3 years' experience with phage, yeast, or other display technology
Strong molecular biology skills, including at least 3 years of hands-on experience with primer design, PCR, construct design, and molecular cloning
Minimum of 3 years' experience with E. coli culture and mammalian cell culture
Minimum of 3 years' experience in development and execution of high throughput screening assays, including ELISA, HTRF, and flow cytometry
Experience (2 years' minimum) with using liquid handling automation and designing automated high throughput screening protocols
Strong time management skills and ability to manage multiple projects in parallel
Strong communication skills and ability to present research in a team setting
Strong computer skills highly desirable, including the creation of robotic protocols
Strong time management skills and ability to manage multiple projects in parallel. 2 years experience in managing multiple projects preferred
Experience with next generation sequencing (NGS) is a plus
Lifting, sitting, standing, walking, bending, handling small laboratory apparatus and liquid handling robots, and ability to perform mathematical calculations and ability to perform complex data analysis.
EEO & Employment Eligibility
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Other Job Details:
Eligible for Relocation Package: yes
Eligible for Employee Referral Bonus: yes
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.