Pfizer Scientist Host in Cambridge, Massachusetts


We are seeking a bright, motivated, and creative scientist to join a fast-paced Inflammation & Immunology team at Pfizer. The successful applicant will have experience in microbiology and molecular or cellular biology, that will be applied to complex co-culture systems. The incumbent will develop assays to interrogate cellular and molecular pathways that underly the pathophysiology of inflammatory and autoimmune disorders, including functional readouts of autophagy and host-microbial interactions. Ultimately, this role will provide relevant knowledge and technical expertise to enable therapeutic discovery efforts aimed at mucosal healing of gut and skin barriers.


  • Develop and execute in vitro human co-culture systems involving multiple cell types to elucidate mechanisms of action for potential therapeutic candidates.

  • Identify, trouble-shoot, and optimize relevant assay systems, technologies, and readouts.

  • Independently design experiments, interpret and track results.

  • Organize, summarize, and present data.

  • Work collaboratively with project teams.


  • B.S. or M.S. in Microbiology, Molecular Biology, Cellular Biology, or related discipline and at least 5 years of experience in an industrial or academic setting.

  • Experience with bacterial and mammalian cell/tissue culture and running cell-based assays.

  • Experience with WB, ELISA, MSD, HTRF, or related protein-based assay systems.

  • Experience with PCR, Taqman, or other gene expression analysis.

  • Highly motivated, independent, analytical.

  • Effective oral and written communication skills, willingness to learn new skills.

  • Ability to adapt quickly to changing project needs.


  • Experience culturing aerobic and anaerobic bacteria, and running bacterial infection assays with mammalian cells.

  • Experience with tissue processing and flow cytometry.

  • Experience harvesting, processing, and analyzing tissues from in vivo disease models.

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