Pfizer Research Scientist Microinjectionist in Cambridge, Massachusetts
Pfizer's in vivo functional genomics unit is focused on rapid generation of transgenic mouse models for validation of new drug targets, mechanistic understanding of disease pathology and preclinical testing. The unit applies the latest technical developments in gene editing and transgenic technology to create First-In-Class genetically engineered mouse models (GEMMs).
The position will be responsible for speedy generation of GEMMs through genome editing in mouse zygotes and will take part in testing and implementation of the latest transgenic technologies.
Support the procedures involved in mouse model generation (embryo production via superovulation, IVF, cryopreservation, electroporation/microinjection, transfer surgery, post-operative care, sampling, genotyping and breeding of animals).
Project tracking and colony management.
Support the testing of new and experimental technologies for creation of animal models, together with other members of the group.
Rigorous compliance with the letter and spirit of all animal welfare and safety protocols.
Bachelor's degree in biology or related field with 7 years of experience, or Master's degree with 5 years of experience
3 years of experience with microinjection, implantation surgery and breeding
Good understanding of all the scientific and practical steps involved in making transgenic models
Ability to engage closely in multiple projects and to track record of timely execution
Excellent interpersonal and communication skills; ability to maintain productive and congenial collaborations in a fast-paced environment
Devotion to advancing team goals and enthusiasm for contributing to the mission of drug discovery
Able to spend significant time at microscope
5 years of experience with microinjection and implantation surgery
Experience in cryopreservation and IVF
Solid understanding of basic molecular biology techniques used for genotyping
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Research and Development