Pfizer Principal Scientist, Translational Modeling and Simulation in Cambridge, Massachusetts
The successful applicant will join the Translational Modeling and Simulation team within Pfizer's Medicine Design organization which applies state-of-the-art modeling and simulation methodologies to preclinical programs to enable key drug discovery decisions from early discovery stages through early -clinical studies. As a member of Cambridge (US)-based multidisciplinary project teams, the candidate will develop and implement quantitative, mechanism-based mathematical models which impact decisions regarding molecular target and interventional modality evaluation, biomarker characterization, chemical optimization and candidate selection, preclinical-clinical translation strategies and early clinical trial design.
As a member preclinical multidisciplinary project teams, develop and implement translational pharmacology and safety strategies in support of the design, characterization and nomination of molecules for clinical development
Influence the design and interpretation of in vitro and in vivo ADME, pharmacology and safety studies underwriting drug design and clinical candidate identification
Hands-on development and implementation of robust, fit-for-purpose mathematical models (e.g. PBPK, PKPD, QSP) to support study design, data analysis and decision making.
Partner with members of early clinical development teams to ensure end-to-end alignment with translational plans, knowledge transfer into early clinical development, and extract learnings from clinical experience.
Partner with other members of Translational Modeling and Simulation to advance the discipline of quantitative translational pharmacology
Partner with members of Pharmacokinetics, Dynamics and Metabolism to advance the discipline of small-molecule ADME sciences
Remain abreast of emerging literature in quantitative translational sciences and present scientific results both internally and externally through conference presentations and publications
Ph.D. or Masters degree in pharmacometrics, pharmaceutical sciences, engineering, applied mathematics, systems pharmacology, physics or similar disciplines where modeling and simulation is emphasized.
3 years with a Phd or 8 years with a Masters degree of relevant experience in practical applications of modeling and simulation (PBPK, PKPD, QSP) in pharmaceutical research and development
Subject matter expertise in the mechanisms of drug disposition, pharmacology and toxicology of small molecule therapeutics.
Strong technical communication skills, ability to work independently and in teams, and attention to detail are essential.
Familiarity with the phases of drug discovery and development, with emphasis on lead optimization, clinical candidate identification/characterization, and early clinical development
- Experience in the application of translational modeling and simulation to areas of inflammation, immunology, cardiovascular, metabolic diseases, rare disease or oncology is desirable, though not required.
Other Job Details:
Eligible for Relocation Package
Eligible for Employee Referral Bonus
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Research and Development