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Pfizer Postdoctoral Fellow, Rare Disease Research Unit in Cambridge, Massachusetts

ROLE SUMMARY

The Rare Disease Research Unit is seeking applicants for a postdoctoral fellow to explore the biology of the rare autosomal recessive disorder Friedreich ataxia. Friedreich ataxia results from the deficient expression of frataxin, a mitochondrial protein involved in iron-sulfur cluster biogenesis. The successful candidate will establish and use models of Friedreich ataxia to identify and characterize cellular modulations that impact the phenotype associated with frataxin deficiency. S/he is expected to have excellent problem solving, critical thinking, and presentation skills (written and oral).

Pfizer's Rare Disease Research Unit (RDRU) is focused on developing therapies for inherited diseases, including neuromuscular and neurodegenerative disorders. The successful candidate will be a member of a group focused on repeat expansion diseases and amyloid diseases.

ROLE RESPONSIBILITIES

  • Design and conduct experiments.

  • Design, complete experimental studies, carry out data analyses and interpretation, record results in electronic lab notebook, and stay abreast of novel relevant findings from the literature.

  • Interface with an internal interdisciplinary group

BASIC QUALIFICATIONS

  • Ph.D. in molecular and cell biology, or a related discipline including primary authorship on relevant publications in peer-reviewed scientific journals.

  • Strong hands-on experience working with and analyzing the phenotype of cellular and in vivo models

  • Strong hands-on experience to establish robust methods in-house.

  • Scientific and technical agility

  • Proficient with standard molecular biology methods including but not limited to cell culture, CRISPR technologies, cloning, plasmid transfections, immunoassays such as western blotting, and quantitative real-time PCR.

  • Ability to generate high quality data in a time-sensitive environment, to assimilate new information from multiple sources, and to effectively communicate results.

  • Creativity, self-motivation and the ability to work independently including analysis and troubleshooting of experimental results and reviewing literature to formulate new approaches.

PREFERRED QUALIFICATIONS

  • Experience working with CRISPR technologies

  • Experience working with rodents, in vivo AAV-mediated expression and histological analyses

  • Experience in mitochondrial biology

#LI-PFE

Other Job Details:

  • Eligible for Employee Referral Bonus (REQUIRED IF BEING OFFERED)

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