Pfizer Manager, Biomarker Statistician, Non in Cambridge, Massachusetts
The role is for a biomarker statistician in the Discovery Genomics and Precision Medicine Statistics group, which explicitly supports Precision Medicine (PM) in Early Clinical Development (ECD). These groups' responsibilities encompass all clinical programs in the East Coast Research Units (RUs) including Internal Medicine, Inflammation and Immunology, Rare Disease, and the Center for Therapeutic Innovation (CTI). Biomarker statisticians in this team will work collaboratively across research, technical, and clinical teams to deliver analytical and computational support for high dimensional biomarker data sets informing early clinical trials.
The individual in this role must communicate effectively with PM scientists and clinicians, and collaborate with colleagues within a matrix organization. They must leverage technical and scientific information from a variety of sources in order to effectively enable data analysis and the scientific interpretation of analysis results, which in turn will be used to drive program decisions.
Briefly, skill sets required for this role include fundamental knowledge of statistical analysis and design, demonstrated ability to create computational tools for data visualization, familiarity with modern multi-dimensional genomic data technologies, and the ability to execute pathway analyses from the results of these types of data.
Collaborate with Precision Medicine (PM) scientists and clinicians in the design, analysis and reporting of multi-dimensional biomarker data in early clinical trials, including assistance with visual summarization and interpretation of results, all done to enable objective decision-making for each clinical program
Defines and evolves best practices across the group and partners with Research Unit, Business Technology (BT) and partner line bioinformatics experts to align approaches, develop best practices and assess and develop new technology.
Responsible for ensuring high-quality data analysis is incorporated into clinical exploratory-research programs in an objective fashion, facilitated by contribution of Exploratory Analysis Plans and summary of results, in partnership with other team members.
Collaborate with research unit scientists in the design, analysis and reporting of genetics and 'omics analyses to enable decision on target selection and prioritization
Partner closely with RUs, Clinical Teams, Statistics, BT and PM functions to identify, pilot and incorporate new bioinformatics tools to support clinical trials QUALIFICATIONS
PhD or equivalent in statistics, computational biology, bioinformatics or related disciplines with minimum of 1 year of experience.
At least 3 months applying statistical methods to the prospective design and analysis of scientific and/or clinical problems. Pharmaceutical or biotech applications desired.
Able to effectively manage a diverse and dynamic workload
Programming skills in R (preferred) or SAS, and at least on scripting language such as Perl, Python, with expertise in big data, data visualization, and web based applications.
Strong working knowledge of high dimensional exploratory biomarker platforms (e.g. transcriptomics, proteomics, flow cytometry, etc.)
Strong knowledge and understanding of statistical analytical methods that can be applied to genetics and omics data analysis.
Strong understanding of clinical study design principles and familiarity working with clinical data in a clinical trial setting.
Expertise in next generation sequencing technologies and data analysis pipeline development
Familiarity/expertise in meta-analysis and potential issues surrounding combining results from different studies, both from a design perspective and in terms of subject ascertainment.
Experience running simulations and mixed models.
Demonstrated ability to develop, influence and champion bioinformatics strategies with scientific team audiences and management.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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Other Job Details:
Eligible for Relocation Package: yes
Eligible for Employee Referral Bonus: yes
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.