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Pfizer Head of the Innate Immunity & Metabolism Group in Cambridge, Massachusetts


Summarize the primary purpose & key accountabilities of the role, including geographical scope (i.e. Global vs. Country/Region). Summary should be concise and include strategic information that would attract candidates to the role. It may be helpful to complete this section after you have finished the other sections of the document.

Within the Internal Medicine Research Unit (IMRU), one of the key strategic focus areas is identifying novel therapies to improve metabolic homeostasis in patients suffering from a range of metabolic diseases, including NASH, cachexia, diabetes, obesity, and abnormalities in cardiac metabolism. Our goal is to build an exciting team focused on deep mechanistic understanding of the aberrant activation of the innate immune system and the link to the pathogenesis of metabolic, inflammatory, and degenerative diseases. The group leader will play a key role in establishing research strategy and projects with the aim to explore the molecular pathways by which innate immune cells coordinate a diverse spectrum of programs in the regulation of systemic metabolism. Research experience in immunology is essential. Demonstrated accomplishments in the field of immunology and metabolism exemplified by high quality publications will be highly desirable. In addition, the group leader will build and facilitate collaborations with partners in the scientific community, as well as within the Pfizer network of scientists focusing on immunology and inflammation research. The group leader will have daily interactions with and supervision of a team of creative and innovative scientists in a supportive environment to conduct rigorous scientific and drug discovery research. Strong self-motivation, excellent communication and interpersonal skills, and the ability to lead and work as part of a team are essential qualities of the role.


In order of importance, indicate the primary responsibilities critical to the performance of the role. It is recommended not to list actual tasks but focus on 5-8 essential responsibilities that highlight accountability and level of judgment required.

Successful candidates will be expected to:

  • Apply scientific expertise and drug discovery experience to impact on future new drug candidate

Discovery and development.

  • Maintain a 'cutting edge' awareness of scientific and technical developments, human genetics, preclinical to clinical translation and apply these where possible to advance the portfolio.

  • Design and conduct studies to increase confidence in human biology for new approaches, and hence

support new idea generation and clinical proof-of-concept studies.

  • Provide strong scientific leadership and experimental guidance to the team from target generation-to-clinical candidate programs.

  • Partners effectively across the Pfizer network, in particular with the Immunology & Inflammation Research Unit and other partner lines. Partners with other RUs to ensure portfolio alignment and maximize on research opportunities.

  • Actively contribute to the external collaborative science strategy, e.g., identify and build collaborations and liaise with external scientists.

  • Engaged and lead a team of diverse in vitro, ex vivo and in vivo biological expertise with scientific rigor.

Demonstrates effective performance management and talent development.

  • The group leader will also be expected to present research findings to the scientific community through consistent publication in peer-reviewed journals and presentation of the results at scientific meetings.


Indicate qualifications that are job related, consistent with business necessity and necessary for the performance of an essential function of this role including: education/licenses/certifications, relevant experience (where legally permissible), technical and/or other job-related skills.

  • Ph.D with 10-15 yrs postdoctoral experience leading a laboratory focused on the discovery of novel pathways in the relevant field in academic or industrial research setting.

  • Applicant must contribute scientifically across a portfolio of disease area projects and help set overall

scientific direction within the group and the broader biology discipline.

  • Applicant should have ability to lead a group of scientists, including 3-4 PhDs, staff scientists, contractors in addition to managing a project team.

  • Drug discovery experience is preferred but not essential.

  • Candidates must utilize disease area/discipline knowledge to contribute to the identification and validation of new therapeutic targets with the goal of achieving proof-of-concept in humans.

  • Candidates should possess strong written/verbal communication skills and ability to effectively collaborate with scientists working in other disciplines including chemistry, drug metabolism,

drug safety and clinical medicine.

  • A demonstrated record of scientific achievement through scientific publications commensurate with position level is required.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.